Representative Publications (last 5 years)

Yin PT, Shah S,  Chhowalla M,  Lee KB. Design, synthesis, and characterization of graphene-nanoparticle hybrid materials for bio-applications. Chemical Reviews. 2015; 7: 2483-2780.

Carrel D, Hernandez K, Kwon M, Mau C, Trivedi MP, Brzustowicz LM, Firestein BL. Nitric oxide synthase 1 adaptor protein, a protein implicated in schizophrenia, controls radial migration of cortical neurons. Biol Psychiatry. 2015; 77: 969-78. PMC4416077.

Ghodbane M, Stucky EC, Maguire TJ, Schloss RS, Shreiber DI, Zahn JD, Yarmush ML. Development and validation of a microfluidic immunoassay capable of multiplexing parallel samples in microliter volumes. Lab on a Chip. 2015; 15: 3211-21. PMC4507421.

Jacobs JZ, Rosado-Lugo JD, Cranz-Mileva S, Ciccaglione K, Tournier V, Zaratiegui M. Arrested replication forks guide retrotransposon integration. Science. 2015; 349: 1549-1553

Ghodbane M, Kulesa A, Yu HH, Maguire TJ, Schloss RR, Ramachandran R, Zahn JD, Yarmush ML. Development of a low volume, highly sensitive microimmunoassay using computational fluid dynamics-driven multiobjective optimization. Microfluidics Nanofluidics. 2015; 18: 199-214. PMC4327895

Olekson MA, Faulknor R, Bandekar A, Sempkowski M, Hsia HC, Berthiaume F. SDF-1 liposomes promote sustained cell proliferation in mouse diabetic wounds. Wound Repair Regen. 2015; 23: 711-23.

Aijaz A, Faulknor R, Berthiaume F, Olabisi RM. Hydrogel microencapsulated insulin-secreting cells increase keratinocyte migration, epidermal thickness, collagen fiber density, and wound closure in a diabetic mouse model of wound healing. Tissue Eng Part A. 2015; 21: 2723-32 PMC4652158

Nelson AG, Zhang X, Ganapathi U, Szekely Z, Flexner CW, Owen A, Sinko PJ. Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment. J Controlled Release. 2015; 10: 219:669-80.

Faulknor RA, Olekson MA, Nativ NI, Ghodbane M, Gray AJ, Berthiaume F. Mesenchymal stromal cells reverse hypoxia-mediated suppression of α-smooth muscle actin expression in human dermal fibroblasts. Biochem Biophys Res Commun. 2015; 458: 8-13.

Tedeschi PM, Lin H, Gounder M, Kerrigan JE, Abali EE, Scotto K, Bertino JR. Suppression of cytosolic NADPH pool by thionicotinamide increases oxidative stress and synergizes with chemotherapy.  Mol Pharmacol. 2015; 88: 720-7. PMC4576680

Tedeschi PM, Vazquez A, Kerrigan JE, Bertino JR. Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression is associated with tumor cell proliferation and is a novel target for drug development. Mol Cancer Res. 2015; 13: 1361-6. PMC4618031

Martin AA, Tomasini M, Kholodovych V, Gu L, Sommerfeld SD, Uhrich KE, Murthy NS, Welsh WJ, Moghe PV. Carbohydrate-derived amphiphilic macromolecules: a biophysical structural characterization and analysis of binding behaviors to model membranes. J Funct Biomaterials. 2015; 6: 171-91. PMC4493506

Stucky EC, Schloss RS, Yarmush ML, Shreiber DI. Alginate micro-encapsulation of mesenchymal stromal cells enhances modulation of the neuro-inflammatory response. Cytotherapy. 2015; 17: 1353-64.

Gray A, Maguire T, Schloss R, Yarmush ML Identification of IL-1β and LPS as optimal activators of monolayer and alginate-encapsulated mesenchymal stromal cell immunomodulation using design of experiments and statistical methods. Biotechnol Prog. 2015; 31: 1058-70. 

O'Neill KM, Akum BF, Dhawan ST, Kwon M, Langhammer CG, Firestein BL. Assessing effects on dendritic arborization using novel Sholl analyses. Front Cell Neurosci. 2015; 9: 285. PMC4519774

McKeon-Fischer KD, Browe DP, Olabisi RM, Freeman JW. Poly(3,4-ethylenedioxythiophene) nanoparticle and poly(ɛ-caprolactone) electrospun scaffold characterization for skeletal muscle regeneration. J Biomed Mater Res A. 2015; 103: 3633-41.

Lewis DR, Petersen LK, York AW, Zablocki KR, Joseph LB, Kholodovych V, Prud'homme RK, Uhrich KE, Moghe PV. Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo. Proc Natl Acad Sci. 2015; 112: 2693-8. PMC4352838

Nguyen J, Papathomas PV, Ravaliya JH, Torres EB. Methods to Explore the Influence of Top-down visual processes on motor behavior.  J Vis Exp. 2014; 16: 86

Naczynski DJ, Tan MC, Riman RE, Moghe PV. Rare earth nanoprobes for functional biomolecular imaging and theranostics. J Mater Chem B Mater Biol Med. 2014; 2: 2958-2973. PMC4048749

Dollé JP, Morrison B 3rd, Schloss RS, Yarmush ML. Brain-on-a-chip microsystem for investigating traumatic brain injury: Axon diameter and mitochondrial membrane changes play a significant role in axonal response to strain injuries. Technology  2014; 2:106. PMC4120884

Barminko JA, Nativ NI, Schloss R, Yarmush ML. Fractional factorial design to investigate stromal cell regulation of macrophage plasticity. Biotechnol Bioeng. 2014; 111: 2239-51.

Nativ NI, Yarmush G, So A, Barminko J, Maguire TJ, Schloss R, Berthiaume F, Yarmush ML Elevated sensitivity of macrosteatotic hepatocytes to hypoxia/reoxygenation stress is reversed by a novel defatting protocol. Liver Transplantation. 2014; 20: 1000-11. PMC4117728

Nativ NI, Chen AI, Yarmush G, Henry SD, Lefkowitch JH, Klein KM, Maguire TJ, Schloss R, Guarrera JV, Berthiaume F, Yarmush ML. Automated image analysis method for detecting and quantifying macrovesicular steatosis in hematoxylin and eosin-stained histology images of human livers. Liver Transplantation. 2014; 20: 228-36  PMC3923430

Khan AG, Whidby J, Miller MT, Scarborough H, Zatorski AV, Cygan A, Price AA, Yost SA, Bohannon CD, Jacob J, Grakoui A, Marcotrigiano J. Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2. Nature. 2014; 509: 381-4.  PMC4126800

Lee S, Dong DX, Jindal R, Mitra B, Maguire T, Schloss R, Yarmush ML. Predicting full thickness skin sensitization using a support vector machine. Toxicology In Vitro. 2014; 28: 1413-23 PMC4470375

Yin PT, Shah BP, Lee KB. Combined magnetic nanoparticle-based microRNA and hyperthermia therapy to enhance apoptosis in brain cancer cells. Small. 2014; 10: 4106-12. PMC4206574

Jacobs JZ, Ciccaglione KM, Tournier V, Zaratiegui M. Implementation of the CRISPR-Cas9 system in fission yeast. Nature Communications. 2014; 5: 5344. PMC4215166

Drzewiecki KE, Parmar AS, Gaudet ID, Branch JR, Pike DH, Nanda V, Shreiber DI. Methacrylation induces rapid, temperaturedependent, reversible self-assembly of type-I collagen. Langmuir. 2014;  30: 11204-11. PMC4172302

Tedeschi PM, Kathari YK, Farooqi IN, Bertino JR. Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts. Cancer Chemother Pharmacol. 2014; 74: 1029-32. PMC4209237

Misenko SM, Bunting SF. Rapid analysis of chromosome aberrations in mouse B lymphocytes by PNA-FISH. J Vis Exp. 2014; 19 10.3791/51806.

Simhadri S, Peterson S, Patel DS, Huo Y, Cai H, Bowman-Colin C, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting SF, Jasin M, Xia B. Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice. J Biol Chem. 2014; 289: 24617-29 PMC4148885

Milberg O, Tora M, Shitara A, Takuma T, Masedunskas A, Weigert R. Probing the role of the actin cytoskeleton during regulated exocytosis by intravital microscopy. Methods Mol Biol. 2014; 1174: 407-21.  PMC4699287

Gonzalez-Flores JN, Shetty SP, Dubey A, Copeland PR. The molecular biology of selenocysteine. Biomol Concepts. 2013; 4: 349-65. PMC4269102

Vazquez A, Tedeschi PM, Bertino JR. Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors. Cancer Res. 2013; 73: 478-82. PMC4083755.

Sweet ES, Langhammer CL, Kutzing MK, Firestein BL. Semiautomated analysis of dendrite morphology in cell culture. Methods Mol Biol. 2013; 1018: 261-8.

Naczynski DJ, Tan MC, Zevon M, Wall B, Kohl J, Kulesa A, Chen S, Roth CM, Riman RE, Moghe PV. Rare-earth-doped biological composites as in vivo shortwave infrared reporters. Nature Communications. 2013; 4: 2199.  PMC3736359

Dollé JP, Morrison B 3rd, Schloss RS, Yarmush ML. A brain slice organotypic uniaxial strain model using microfluidics. Lab on a Chip. 2013; 13: 432-42. PMC3546521

Nativ NI, Yarmush G, Chen A, Dong D, Henry SD, Guarrera JV, Klein KM, Maguire T, Schloss R, Berthiaume F, Yarmush ML. Rat hepatocyte culture model of macrosteatosis: effect of macrosteatosis induction and reversal on viability and liverspecific function. J Hepatol. 2013; 59: 1307-14. PMC3899833

Langhammer CG, Kutzing MK, Luo V, Zahn JD, Firestein BL. A topographically modified substrate-embedded MEA for directed myotube formation at electrode contact sites. Ann Biomed Eng. 2013; 41: 408-20. PMC3816097.

Chen A, Nikitczuk K, Nikitczuk J, Maguire T, Yarmush M. Portable robot for autonomous venipuncture using 3D near infrared image guidance. Technology.  2013; 1: 72-87. PMC4482475

Sasso LA, Aran K, Guan YL, Undar A,  Zahn JD.  Continuous monitoring of inflammation biomarkers during simulated cardiopulmonary bypass using a microfluidic immunoassay device - a pilot study. Artificial Organs.  2013; 37: E9-E17.  PMC3545401

Lewis DR, Kholodovych V, Tomasini MD, Abdelhamid D, Petersen LK, Welsh WJ, Uhrich KE, Moghe PV. In silico design of antiatherogenic biomaterials. Biomaterials. 2013; 34: 7950-9. PMC3880781.

Macabenta FD, Jensen AG, Cheng YS, Kramer JJ, Kramer SG. Frazzled/DCC facilitates cardiac cell outgrowth and attachment during Drosophila dorsal vessel formation. Dev Biol. 2013; 380: 233-42.  PMC4137861.

Tedeschi PM, Markert EK, Gounder M, Lin H, Dvorzhinski D, Dolfi SC, Chan LL, Qiu J, DiPaola RS, Hirshfield KM, Boros LG, Bertino JR, Oltvai ZN, Vazquez A. Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell Death Dis. 2013; 4:e877. PMC3920946.

Nikitczuk KP, Schloss RS, Yarmush ML, Lattime EC.PLGA-polymer encapsulating tumor antigen and CpG DNA administered into the tumor microenvironment elicits a systemic antigen-specific IFN-γ response and enhances survival. J Cancer Ther. 2013; 4: 280-290. PMC3670804

Toth ML, Melentijevic I, Shah L, Bhatia A, Lu K, Talwar A, Naji H, Ibanez-Ventoso C, Ghose P, Jevince A, Xue J, Herndon LA, Bhanot G, Rongo C, Hall DH, Driscoll M. Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system. J Neurosci. 2012; 32: 8778-90 PMC3427745

Gonzalez-Flores JN, Gupta N, DeMong LW, Copeland PR. The selenocysteine-specific elongation factor contains a novel and multi-functional domain. J Biol Chem. 2012; 287: 38936- 45.  PMC3493934.

Kutzing MK,  Luo V, Firestein BL. Protection from glutamate induced excitotoxicity by memantine. Ann Biomed Eng. 2012; 40: 1170-81. PMC4217523.

Chen A, Yarmush ML, Maguire T. Physiologically based pharmacokinetic models: integration of in silico approaches with micro cell culture analogues. Curr Drug Metab. 2012; 13: 863- 80. PMC3966908

Masand SN, Chen J, Perron IJ, Hammerling BC, Loers G, Schachner M, Shreiber DI. The effect of glycomimetic functionalized collagen on peripheral nerve repair. Biomaterials. 2012; 33: 8353-62. PMCID:PMC3623557.

Sasso LA, Johnston IH, Zheng M, Gupte RK, Ündar A, Zahn JD. Automated microfluidic processing platform for multiplexed magnetic bead immunoassays. Microfluidics Nanofluidics. 2012;  13: 603-612. PMC4564126.

Masand SN, Perron IJ, Schachner M, Shreiber DI. Neural cell type-specific responses to glycomimetic functionalized collagen  Biomaterials. 2012; 33: PMC3225205

York AW, Zablocki KR, Lewis DR, Gu L, Uhrich KE, Prud'homme RK, Moghe PV. Kinetically assembled nanoparticles of bioactive macromolecules exhibit enhanced stability and cell-targeted biological efficacy. Adv Mater. 2012; 24:733-9. PMC3495129

Nativ NI, Maguire TJ, Yarmush G, Brasaemle DL, Henry SD, Guarrera JV, Berthiaume F, Yarmush ML.Liver defatting: an alternative approach to enable steatotic liver transplantation. Am J Transplant. 2012; 12: 3176-83. PMC4047986

Sharma N, Jindal R, Mitra B, Lee S, Li L, Maguire TJ, Schloss R, Yarmush ML. Perspectives on non-animal alternatives for assessing sensitization potential in allergic contact dermatitis. Cellular & Molecular Bioengineering. 2012; 5: 52-72. PMC3985137.

Langhammer CG, Kutzing MK, Luo V, Zahn JD, Firestein BL. Skeletal myotube integration with planar microelectrode arrays in vitro for spatially selective recording and stimulation: a comparison of neuronal and myotube extracellular action potentials. Biotechnol Prog. 2011; 27: 891-5.  PMC4557870

Masand SN, Mignone L, Zahn JD, Shreiber DI. Nanoporous membrane-sealed microfluidic devices for improved cell viability. Biomed Microdevices  2011; 13: 955-61.

Della Valle MC, Sleat DE, Zheng H, Moore DF, Jadot M, Lobel P. Classification of subcellular location by comparative proteomic analysis of native and density-shifted lysosomes. Mol Cell Proteomics. 2011; 4: M110.006403. PMC3069348

Sundararaghavan HG, Masand SN, Shreiber DI. Microfluidic Generation of Haptotactic Gradients through 3D Collagen Gels for Enhanced Neurite Growth. J Neurotrauma. 2011; 8: 2377-87. PMC3218382

Moloughney JG, Monken CE, Tao H, Zhang H, Thomas JD, Lattime EC, Jin SV. Vaccinia virus leads to ATG12-ATG3 conjugation and deficiency in autophagosome formation. Autophagy. 2011; 1434-1437.  PMC3327614

Iverson NM, Plourde NM, Sparks SM, Wang J, Patel EN, Shah PS, Lewis DR, Zablocki KR, Nackman GB, Uhrich KE, Moghe PV. Dual use of amphiphilic macromolecules as cholesterol efflux triggers and inhibitors of macrophage athero-inflammation. Biomaterials. 2011; 32: 8319-27. PMC3167147.

Sharma NS, Nagrath D, Yarmush ML. Metabolic profiling based quantitative evaluation of hepatocellular metabolism in presence of adipocyte derived extracellular matrix. PLoS One. 2011; 6: e20137 PMC3095641

Sweet ES, Previtera ML, Fernández JR, Charych EI, Tseng CY, Kwon M, Starovoytov V, Zheng JQ, Firestein BL. PSD-95 alters microtubule dynamics via an association with EB3. J Neurosci. 2011; 31: 1038-47. PMC3138189

Barminko J, Kim JH, Otsuka S, Gray A, Schloss R, Grumet M, Yarmush ML. Encapsulated mesenchymal stromal cells for in vivo transplantation in spinal cord injury. Biotechnol Bioeng. 2011; 108: 2747-58. PMC3178737.

Banerjee I, Sharma N, Yarmush ML. Impact of co-culture on pancreatic differentiation of embryonic stem cells. J Tissue Eng Regen Med, 2011; 5: 313-23..